vegan is not about eating beans. I myself seldom eat them because
of the gastrointestinal symptoms they cause. There's plenty of protein
in vegetables (particularly leafy greens).
is a very problematic area and one in which the angels fear to tread,
mostly because the territory has been staked out by dieticians who
believe that since protein intake must be limited, that the small
amount that is allowed must be "high quality" protein.
In their minds this still means animal protein although there's
little evidence that there's any real difference in the quality
of diverse plant proteins and animal protein.
In my opinion,
animal protein is probably what started your friend's problems in
the first place. Type 1 diabetes is an autoimmune disease in which
the beta cells of the pancreas are wiped out by the body's own immune
system. Recent studies suggest that dairy proteins are one of the
triggers (see below). Plant proteins can also jiggle the immune
system but since the amino acid sequence of the proteins is so much
different from human proteins the result is usually just allergy,
a minor annoyance.
I think, but
cannot prove, that the continued feeding of animal protein in the
face of renal disease is like trying to put out a fire by throwing
gasoline on it. The antigen-antibody complexes that destroy the
renal architecture, particularly the gossamer membranes of the glomerulus,
will continue to accumulate as long as animal foods are consumed.
If this is correct then a vegan diet is the proper solution.
complexity of renal failure, which requires that the serum levels
of phosphorus, calcium, protein, and many other laboratory values
be carefully watched, means that the switch to a vegan diet can
only be safely made with the assistance of the patient's health
providers. If they can't be persuaded to try it then it's probably
not wise to try it on your own.
Below are some
references that might be helpful. Good luck.
A special, supplemented
'vegan' diet for nephrotic patients. Barsotti G; Morelli E; Cupisti
A; Bertoncini P; Giovannetti S Istituto di Clinica Medica 1, Universita
di Pisa, Italy.
Am J Nephrol
1991, 11 (5) p380-5, ISSN 0250-8095 Journal Code: 3MB
Document type: JOURNAL ARTICLE
JOURNAL ANNOUNCEMENT: 9207
Subfile: INDEX MEDICUS
protein intake, in the past recommended for nephrotic syndrome,
does not improve hypoproteinemia and may accelerate progressive
renal damage. In contrast, low-protein diets reduce proteinuria
and preserve renal function in experimental renal models of nephrotic
syndrome. In this study, 20 steroid-resistant, nephrotic patients
were treated with a pure vegetarian, low-protein diet, supplemented
with essential amino acids and ketoanalogues (supplemented vegan
diet, SVD) for 4.6 +/- 3.1 months. Before the study, these patients
followed an unrestricted protein, low-sodium diet (LSD). Proteinuria,
daily urea nitrogen excretion and creatinine clearance decreased
significantly on SVD. A similar lowering effect of SVD was observed
on serum total cholesterol. Seven of the 20 patients changed from
LSD to SVD and vice-versa on 3 occasions, and in all cases, we found
an increase of proteinuria during the LSD period. Serum albumin,
HDL cholesterol, triglycerides and anthropometric measurements did
not change on SVD. Our data suggest that SVD exerts a favorable
effect on proteinuria and hypercholesterolemia in nephrotic patients,
without inducing clinical or laboratory signs of malnutrition.
anti-bovine serum albumin antibodies in type 1 (insulin-dependent)
diabetes mellitus are detected by particle concentration fluoroimmunoassay,
and not by enzyme linked immunoassay.
J; Saukkonen T; Savilahti E; Dosch HM
Department of Immunology and Cancer, Hospital for Sick Children,
Toronto, Ontario, Canada.
(GERMANY) Oct 1992, 35 (10) p985-90, ISSN 0012-186X
Document type: JOURNAL ARTICLE
JOURNAL ANNOUNCEMENT: 9303
Subfile: INDEX MEDICUS
developed a particle concentration fluoroimmunoassay for the measurement
of serum antibodies to bovine serum albumin in patients with Type
1 (insulin-dependent) diabetes mellitus. We observed elevated IgG-anti-bovine
serum albumin antibodies in 100% of newly-diagnosed diabetic children
and in 2.5% of matched control children. Here we compare the fluoroimmunoassay
and the more commonly available enzyme linked immunoassay technique,
exchanging coded serum samples from 40 newly-diagnosed diabetic
children and 179 control children between two laboratories. Particle
concentration fluoroimmunoassay detected elevated IgG-anti-bovine
serum albumin antibodies in all diabetic children, enzyme immunoassay
in 25% (p less than 0.0001). Fluoroimmunoassay detected elevated
levels in 2.2% and enzyme immunoassay in 10% of control children
(p less than 0.002). Elevated IgA-anti-bovine serum albumin antibodies
in patients were slightly more often detected by fluoroimmunoassay
than by enzyme immunoassay, while in control children enzyme immunoassays
detected elevated levels three times more often (p less than 0.01).
Values measured in either assay showed overall no correlation in
either patient (IgG:rs = 0.28; IgA:rs = 0.11) or control sera (IgG:rs
= 0.02; IgA:rs = -0.05). Fluoroimmunoassay for IgG was 100% disease-sensitive
(enzyme immunoassay: 25%, p less than 0.0001) and more disease-specific
(IgG; p less than 0.02). Our findings demonstrate that these assay
techniques detected distinct subsets of anti-bovine serum albumin
antibodies with little (IgG) or some (IgA) overlap. In fluoroimmunoassay
procedures, antigen:antibody binding occurs within 1-2 min while
hours are allowed in an enzyme immunoassay.(ABSTRACT TRUNCATED AT
A bovine albumin
peptide as a possible trigger of insulin-dependent diabetes mellitus
J; Martin JM; Knip M; Ilonen J; Robinson BH; Savilahti E; Akerblom
HK; Dosch HM
Sick Children, Department of Pediatrics and Immunology, University
of Toronto, ON, Canada.
N Engl J Med
Jul 30 1992, 327 (5) p302-7, ISSN 0028-4793
Comment in N
Engl J Med 1992 Jul 30;327(5):348-9
Document type: JOURNAL ARTICLE
JOURNAL ANNOUNCEMENT: 9210
Subfile: AIM; INDEX MEDICUS BACKGROUND.
has been implicated as a possible trigger of the autoimmune response
that destroys pancreatic beta cells in genetically susceptible hosts,
thus causing diabetes mellitus. Studies in animals have suggested
that bovine serum albumin (BSA) is the milk protein responsible,
and an albumin peptide containing 17 amino acids (ABBOS) may be
the reactive epitope. Antibodies to this peptide react with p69,
a beta-cell surface protein that may represent the target antigen
for milk-induced beta-cell--specific immunity. METHODS. We used
immunoassays and Western blot analysis to analyze anti-BSA antibodies
in the serum of 142 children with insulin-dependent diabetes mellitus,
79 healthy children, and 300 adult blood donors. Anti-ABBOS antibodies
were measured in 44 diabetic patients at the time of diagnosis,
three to four months later, and one to two years later. RESULTS.
All the diabetic patients had elevated serum concentrations of IgG
anti-BSA antibodies (but not of antibodies to other milk proteins),
the bulk of which were specific for ABBOS. The mean (+/- SE) concentration
was 8.5 +/- 0.2 kilofluorescence units (kfU) per microliter, as
compared with 1.3 +/- 0.1 kfU per microliter in the healthy children.
IgA antibodies were elevated as well, but not IgM antibodies. The
antibody concentrations declined after diagnosis, reaching normal
levels in most patients within one to two years. The initial decline
involved anti-ABBOS--specific antibodies almost exclusively. Much
lower serum concentrations of anti-BSA antibodies were found in
all 379 control subjects, but only 2.5 percent of them had small
amounts of ABBOS-specific IgG. CONCLUSIONS. Patients with insulin-dependent
diabetes mellitus have immunity to cow's-milk albumin, with antibodies
to an albumin peptide that are capable of reacting with a beta-cell--specific
surface protein. Such antibodies could participate in the development
of islet dysfunction.
proteinuric patients with a vegetarian soy diet and fish oil.
Fellin G, Cofano F, Delle Fave A, Manna G, Ciceri R, Petrini C,
Lavarda F, Pozzi F, D'Amico G
Nephrology, San Carlo Hospital, Milano, Italy.
Our aim was
to determine whether a longer period of treatment with a vegetarian
soy diet with addition of fish oil supplements would accentuate
the beneficial effects on hyperlipidemia and proteinuria of nephrotic
patients we found in a previous study. After an 8-week baseline
period on free diet, patients were randomly allocated either on
soy diet alone (SD) or to SD plus 5 g/day of fish oil (SD + FO)
orally for two months. Then they crossed over to the other treatment
for two additional months. They finally resumed eating the free
diet for 3 months. We selected 20 outpatients with chronic glomerulonephritis,
proteinuria in the nephrotic range, fasting serum cholesterol >
250 mg/dl, mean serum creatinine concentrations 1.75 +/- 0.23 mg/dl.
Serum lipid profile, urinary protein loss and nutritional parameters
were monitored. With the soy diet, we obtained a significant decrease
both of hyperlipidemia and of proteinuria. The effect of the soy
diet on proteinuria increased over the 4 months. The addition of
a moderate amount (5 g/day) of fish oil in a randomized cross-over
design had no further beneficial effect. Stability of serum albumin,
transferrin and the body mass index documented good nutritional
status. In conclusion, the dietary manipulation with our vegetarian
soy diet confirmed the beneficial effects on hyperlipidemia and
proteinuria of nephrotic patients. Such effects persisted and even
ameliorated after 4 months of diet. The addition of moderate oral
supplements of fish oil did not potentiate the beneficial effect.
Randomized controlled trial
Nutr Rev 1993
for treating nephrotic syndrome.
School of Medicine, New England Medical Center Hospitals, Boston,
based on soy-protein appeared to be effective in treating the hyperlipidemia
of nephrotic syndrome. Whether there is a unique effect of soy or
whether all very low-fat, low-saturated-fat, low-cholesterol, and
low-protein diets have similar effects remains unknown.
Harris MD received a degree in physics from the University of
California Berkeley, where he earned Phi Beta Kappa honors. He received
his degree in medicine from the University of California at San
Francisco, and received his postgraduate training at San Diego County
Hospital. He holds a Medical License in the State of Hawaii. He
has been an Emergency Department physican since 1963, and the Director
of the Kaiser Permanente Vegan Lifestyle Clinic on Oahu until his
retirement in 1998. Dr. Harris is the author of The Scientific Basis
In addition, he was the 1950 Big Ten Trampoline Champion, is
an accomplished hangglider and commercial pilot, and at age 70 became
a skydiver with 108 jumps to date. Dr. Harris has been vegetarian
since 1950, and vegan since 1963.
Dr. Harris is one of the VegSource experts who will be speaking
at the upcoming VegSource