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From: TSS ()
Subject: UK & USA National CJD Surveillance Unit - Mon 5 Nov 2007
Date: November 6, 2007 at 7:30 am PST

PRION DISEASE UPDATE 2007 (07)
******************************
A ProMED-mail post

ProMED-mail is a program of the
International Society for Infectious Diseases

[Note: With continuing decline of the number of cases of variant
Creutzfeldt-Jacob disease (abbreviated previously as vCJD or CJD (new
var.) in ProMED-mail) in the human population, it has been decided to
broaden the scope of the occasional ProMED-mail reports to include
other prion-related diseases. These updates supersede the previous
update thread.

The definitions of the designations deaths, definite cases, probable
vCJD cases, can be found by accessing the Department of Health website
()
or by reference to a previous ProMED-mail post in the vCJD thread.

Data on vCJD cases from any part of the world are now included in
these updates where appropriate, and other forms of CJD (sporadic,
iatrogenic, familial, and GSS Gerstmann-Straussler-Scheinker disease)
are included also when they have some relevance to the incidence and
etiology of vCJD.

In addition, prion-related diseases of domesticated and free-living
animals may also be included if relevant. - Mod.CP]

In this update:

[1] UK: National CJD Surveillance Unit - Monthly statistics
[2] USA: National Prion Disease Pathology Surveillance Center

******
[1] UK National CJD Surveillance Unit - Monthly statistics
Date: Mon 5 Nov 2007
Source: UK National CJD Surveillance Unit, Monthly Statistics, 2007 [edited]


Monthly Creutzfeldt-Jakob disease statistics - as of 2 Nov 2007

[N.B. The Department of Health ceased issuing monthly CJD press
notices at the end of September 2007 because the same data are also
published by the National CJD Surveillance Unit in Edinburgh at
.]

These following figures show the number of suspect cases of CJD
referred to the CJD surveillance unit in Edinburgh and the number of
deaths of definite and probable variant Creutzfeldt-Jakob disease
[abbreviated in ProMED-mail as CJD (new var.) or vCJD], the form of
the disease thought to be linked to BSE (bovine spongiform encephalopathy).

Definite and probable vCJD cases in the UK as of 2 Nov 2007
----------------------

Summary of vCJD cases -- deaths
----------------------
Deaths from definite vCJD (confirmed): 114
Deaths from probable vCJD (without neuropathological confirmation): 47
Deaths from probable vCJD (neuropathological confirmation pending): 1
Number of deaths from definite or probable vCJD (as above): 162

Summary of vCJD cases -- alive
----------------------
Number of probable vCJD cases still alive: 4

Total
-----
Number of definite or probable vCJD (dead and alive): 166

These data indicate that there have been no new cases diagnosed
during the past month, but one patient has died, raising the vCJD
death toll to 162.

These data are still consistent with the view that the vCJD outbreak
in the UK is in decline. The peak number of deaths was 28 in the year
2000, followed by 20 in 2001, 17 in 2002, 18 in 2003, 9 in 2004, 5 in
2005, 5 in 2006, and so far 4 in 2007.

Totals for all types of CJD cases in the year 2007 so far
-----------------------------
As of 2 Nov 2007 in the UK in the year 2007, so far there have been
93 referrals, 38 deaths from sporadic CJD, 2 deaths from iatrogenic
CJD, 2 deaths from familial CJD, one from GSS, and 4 deaths from vCJD.

--
Communicated by:
ProMED-mail

******
[2] USA: National Prion Disease Pathology Surveillance Center
Date: June 2007
Source: National Prion Disease Pathology Surveillance Center (USA) [edited]


CJD Cases examined
----------------------
Year / Referrals / Prion disease / Sporadic / Familial / Iatrogenic / vCJD

1996 / 42 / 32 / 26 / 4 / 0 / 0
1997 / 115 / 68 / 57 / 9 / 0 / 0
1998 / 93 / 53 / 45 / 7 / 1 / 0
1999 / 114 / 69 / 61 / 8 / 0 / 0
2000 / 151 / 103 / 89 / 14 / 0 / 0
2001 / 208 / 116 / 106 / 9 / 0 / 0
2002 / 255 / 143 / 118 / 23 / 2 / 0
2003 / 272 / 174 / 132 / 41 / 0 / 0
2004 / 334 / 183 / 157 / 21 / 0 / 1*
2005 / 352 / 195 / 152 / 37 / 1 / 0
2006 / 372 / 186 / 143 / 30 / 0 / 1**
2007 / 120 / 68 / 35 / 7 / 0 / 0
TOTAL / 2428*** / 1390**** / 1121 / 210 / 4 / 2

*Acquired in UK
** Acquired in Saudi Arabia
*** Includes 17 inconclusive and 9 pending (1 from 2006, 8 from 2007.
**** Includes 17 non-vCJD type unknown (2 from 1996, 2 from 1997, 1
from 2001, 1 from 2003, 4 from 2004, 3 from 2005, 4 from 2006) and 36
type pending (2 from 2005, 8 from 2006, 26 from 2007).

Notes:

-- Cases are listed based on the year of death when available. If the
year of death is not available, the year of sample receipt is used.

-- Referrals: Cases with possible or probable prion disease from
which brain tissue or blood in the case of familial disease were submitted.

-- Inconclusive: Cases in which the samples were not sufficient to
make a diagnosis.

-- Non-vCJD type unknown are cases in which the tissue submitted was
adequate to establish the presence but not the type; in all cases,
vCJD could be excluded.

--
Communicated by:
Terry S. Singeltary Sr.

[In submitting these data, Terry S. Singeltary Sr. draws attention to
the steady increase in the "type unknown" category, which, according
to their definition, comprises cases in which vCJD could be excluded.
The total of 26 cases for the current year (2007) is disturbing,
possibly symptomatic of the circulation of novel agents.
Characterization of these agents should be given a high priority. - Mod.CP]

[see also:
Prion disease update 2007 (06) 20071003.3269
Prion disease update 2007 (05) 20070901.2879
Prion disease update 2007 (04) 20070806.2560
Prion disease update 2007 (03) 20070702.2112
Prion disease update 2007 (02) 20070604.1812
Prion disease update 2007 20070514.1542
CJD (new var.) update 2007 (05) 20070403.1130
CJD (new var.) update 2007 (04) 20070305.0780
CJD (new var.) update 2007 (03) 20070205.0455
CJD (new var.) update 2007 (02): South Korea, susp 20070115.0199
2006
----
CJD (new var.), blood transfusion risk 20061208.3468
CJD, transmission risk - Canada (ON) 20061207.3457
CJD (new var.) update 2006 (12) 20061205.3431
CJD (new var.) update 2006 (11) 20061106.3190
CJD (new var.) update 2006 (10) 20061002.2820
CJD (new var.) - Netherlands: 2nd case 20060623.1741
CJD (new var.) - UK: 3rd transfusion-related case 20060209.0432
CJD (new var.) update 2006 (02) 20060206.0386
CJD (new var.) update 2006 20060111.0101
2005
----
CJD (new var.) update 2005 (12) 20051209.3547
CJD (new var.) update 2005 (11) 20051108.3270
CJD (new var.) update 2005 (10) 20051006.2916
CJD (new var.) update 2005 (02) 20050211.0467
CJD (new var.) - UK: update 2005 (01) 20050111.0095
2004
----
CJD, genetic susceptibility 20041112.3064
CJD (new var.) - UK: update 2004 (14) 20041206.3242
CJD (new var.) - UK: update 2004 (10) 20040909.2518
CJD (new var.) - UK: update 2004 (02) 20040202.0400
CJD (new var.) - UK: update 2004 (01) 20040106.0064
CJD (new var.) - France: 8th case 20041022.2864
CJD (new var.) - France: 9th case 20041123.3138
CJD (new var.), blood supply - UK 20040318.0758
CJD (new var.), carrier frequency study - UK 20040521.1365
2003
----
CJD (new var.) - UK: update 2003 (13) 20031216.3072
CJD (new var.) - UK: update 2003 (01) 20030108.0057
2002
----
CJD (new var.) - UK: update Dec 2002 20021207.5997
CJD (new var.) - UK: update Jan 2002 20020111.3223
2001
----
CJD (new var.), incidence & trends - UK (02) 20011124.2875
CJD (new var.), incidence & trends - UK 20011115.2816
CJD (new var.) - UK: reassessment 20011029.2671
CJD (new var.) - UK: update Oct 2001 20011005.2419
CJD (new var.) - UK: regional variation (02) 20010907.2145
CJD (new var.) - UK: update Sep 2001 20010906.2134
CJD (new var.) - UK: update Aug 2001 20010808.1872
CJD (new var.) - UK: 9th Annual Report 20010628.1231
CJD (new var.) - UK: update June 2001 20010622.1188
CJD (new var.) - UK: update 3 Jan 2001 20010104.0025]
....................................................cp/msp/dk

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Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in
the United States


http://cjdusa.blogspot.com/


i am reminded of a few things deep throat (high ranking official at usda)
told me years ago;


==========================================


The most frightening thing I have read all day is the
report of Gambetti's finding of a new strain of
sporadic cjd in young people.........Dear God,


https://www.blogger.com/comment.g?blogID=7842737484277562285&postID=5759550357128128100


TSS




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