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From: TSS ()
Subject: Role of the CD8+ dendritic cell subset in transmission of prions
Date: February 15, 2007 at 9:32 am PST

J. Virol. doi:10.1128/JVI.02345-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.


Role of the CD8+ dendritic cell subset in transmission of prions

Shneh Sethi, Kristen M. Kerksiek, Thomas Brocker, and Hans Kretzschmar*
Center for Neuropathology and Prion Research, Institute of Immunology, Ludwig Maximilians University, München

* To whom correspondence should be addressed. Email: Hans.Kretzschmar@med.unimuenchen.de .


Abstract


Controversial results have been observed in mouse models regarding the role of lymphoid tissues in prion pathogenesis. To investigate the role of dendritic cells (DC), we used a transgenic mouse model. In this model (CD11c-N17Rac1), a significant reduction of CD8+ CD11chi DC has been described, and remaining CD8+ DC demonstrate reduced capacity for uptake of apoptotic cells. After intraperitoneal prion-infection significantly longer incubation times were observed in CD11c-N17Rac1 mice than in controls, indicating that a defect in CD8+ CD11chi DC significantly impedes neuroinvasion after intraperitoneal infection. In contrast, no distinct differences were observed between CD11c-N17Rac1 mice and controls after oral infection. This provides evidence that oral and intraperitoneal prion infection differ in lymphoreticular requirements.

http://jvi.asm.org/cgi/content/abstract/JVI.02345-06v1?papetoc


TSS




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