Follow Ups | Post Followup | Back to Discussion Board | VegSource
See spam or
inappropriate posts?
Please let us know.

From: TSS ()
Subject: Role of the CD8+ dendritic cell subset in transmission of prions
Date: February 15, 2007 at 9:32 am PST

J. Virol. doi:10.1128/JVI.02345-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Role of the CD8+ dendritic cell subset in transmission of prions

Shneh Sethi, Kristen M. Kerksiek, Thomas Brocker, and Hans Kretzschmar*
Center for Neuropathology and Prion Research, Institute of Immunology, Ludwig Maximilians University, München

* To whom correspondence should be addressed. Email: .


Controversial results have been observed in mouse models regarding the role of lymphoid tissues in prion pathogenesis. To investigate the role of dendritic cells (DC), we used a transgenic mouse model. In this model (CD11c-N17Rac1), a significant reduction of CD8+ CD11chi DC has been described, and remaining CD8+ DC demonstrate reduced capacity for uptake of apoptotic cells. After intraperitoneal prion-infection significantly longer incubation times were observed in CD11c-N17Rac1 mice than in controls, indicating that a defect in CD8+ CD11chi DC significantly impedes neuroinvasion after intraperitoneal infection. In contrast, no distinct differences were observed between CD11c-N17Rac1 mice and controls after oral infection. This provides evidence that oral and intraperitoneal prion infection differ in lymphoreticular requirements.


Follow Ups:

Post a Followup

E-mail: (optional)


Optional Link URL:
Link Title:
Optional Image URL: