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From: TSS ()
Subject: A case of scrapie in a sheep carrying the lysine-171 allele PrP
Date: August 16, 2006 at 6:33 am PST

A case of scrapie in a sheep carrying the lysine-171 allele of the prion protein gene

P. L. Acutis1, F. Martucci1, M. Mazza1, S. Peletto1, B. Iulini1, C. Corona1, E. Bozzetta1, C. Casalone1 and M. Caramelli1

(1) CEA – Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Torino, Italy

Received: 29 July 2005 Accepted: 27 February 2006 Published online: 30 March 2006

Summary. Susceptibility to scrapie in sheep depends on the host PrP genotype. No data about the linkage of the rare ARK allele to differential scrapie susceptibility are currently available. Several tissues isolated from sheep from an Italian scrapie outbreak and carrying the ARK allele were examined for the presence of the pathological prion protein. A weak positivity was detected only by Western blot in the brainstem of one ARK/ARH sheep. This result shows that the ARK allele does not confer full resistance against scrapie and that the allele needs to be studied further before it can be considered for breeding purposes.





http://www.springerlink.com/content/084l832600t50j67/


TSS

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